In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo.

?In vitro Experiments on the Effects of Mouse Sarcomas 180 and 37 on the Spinal and Sympathetic Ganglia of the Chick Embryo? were experiments conducted by Rita LeviMontalcini [3] in conjunction with Viktor Hamburger [4] and Hertha Meyer [5] and published in Cancer Research in 1954. In this series of experiments, conducted at the University of Brazil [6] , Levi-Montalcini demonstrated increased nerve growth by introducing specific tumors (sarcomas) to chick [7] ganglia. Ganglia are clusters of nerve cells [8], from which nerve fibers emerge. This work led to the discovery of nerve growth factor [9] (NGF) and later the Nobel Prize in Physiology or Medicine [10] in 1986.